Exact(2)
Both techniques rely heavily on detailed maps of chromosomal regions, initially to understand the scope of the regions being modified and finally to provide the cloned resources necessary to allow both finished sequencing and large insert complementation.
High-throughput technologies can effectively replace cytogenetics to generate high-resolution maps of chromosomal aberrations.
Similar(6)
Using both a chromosome-based cladistic analysis as well as by mapping of chromosomal differences onto a molecular-based phylogenetic tree, we revealed a number of potential cytogenetic signatures that support the clade of Pandionidae (PHA) + Accipitridae.
Snyder's laboratory at Yale specializes in the large-scale analysis of proteins using microarrays and global mapping of chromosomal protein binding sites.
Our results form the first global map of chromosomal interactions in a eukaryotic nucleus and demonstrate the highly connected nature of the yeast genome.
To understand the role of DSBs in multiple cellular mechanisms, a robust method for genome-wide mapping of chromosomal breaks at one-nucleotide resolution is required.
In this work, we report a fine mapping of chromosomal imbalances in a set of 27 BL primary tumors and cell lines.
Thus, based on genome wide SNP arrays, fine mapping of chromosomal breakpoints and subsequent identification of the specific genes recurrently altered (deleted, gained or amplified) is achieved for individual samples.
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