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Exact(5)
A hub protein is one that interacts with many functional partners.
IL-10 has many functional partners, one of which is the α2-macroglobulin (A2M).
These identified metabolites in the profiles are usually well-studied metabolites which tend to have many functional partners in the network.
Metabolites involved in a number of pathways usually have many functional partners, while other metabolites only participate in a few pathways and thus have few functional-compensation partners.
In contrast, if the metabolites in a pathway tend to have many functional partners in the biological network, the dysregulation signal is more likely to be alleviated.
Similar(55)
For example, the sine oculis homeobox homolog 3 (SIX3) was observed with many potential functional partners or related proteins.
However, if a protein binds promiscuously to many non-functional partners, variable expression of that protein may be extremely disruptive to diverse processes, also leading to a negative correlation, in this case between the number of false positive PPIs and noise.
However, many compensatory mutations were not among functional partners, and these have no obvious explanation, even following investigation with subsequent genetic manipulations and adaptations.
Many of the compensatory changes were among the functional partners of the missing gene.
Not surprisingly, many functional similarities exist.
For each gene, we detect its nearest functional partners (NFPs).
Related(20)
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many functional limitations
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many many partners
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