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Here we discuss the definition of LAPs, review their many binding partners, elaborate their functions in nuclear architecture, chromatin organization, gene expression and signaling, and describe what is currently known about their links to human disease.
Disordered regions allow proteins to have many binding partners and different functions based upon the conformations.
The actual chance of sharing a target is likely to be higher because only the drug-target information documented in the DrugBank was used, many binding partners for known drugs are not documented by DrugBank or not known yet and were thus counted as false negatives.
In SCA1, both wild-type and expanded ATXN1 share many binding partners (Lim et al., 2006).
The complex structure of the core protein invites many binding partners.
IDPs are known to have many binding partners due to their flexibility of conformation [ 31].
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First, their capacity to structurally adapt to many different binding partners matches the need for chaperones to bind a wide range of proteins.
Indeed, the Dvl PDZ domain can bind to Dvl C-terminus, Fz C-terminal tail, and many other binding partners.
RACK1 is a member of the tryptophan-aspartate (WD) repeat family and is a scaffolding protein with many known binding partners and functions [16].
Interactions between E6 and its many cellular binding partners contribute to viral propagation and the possible progression to cancer.
For example, changes in the relative orientation of protein domains make it possible to create distinct binding surfaces for intermolecular interactions with many different binding partners.
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