There are indications that many functional brain disorders, including ASD and IDD, are developmental in nature, because they present soon after birth (Konopka et al., 2012; Ploeger et al., 2010).
Over the past decades, multiple lines of research have identified the locus for many functional, chronic pain disorders to the central nervous system, and the brain.
Over the past decades, multiple lines of research have identified the locus for many functional, chronic pain disorders as the central nervous system, and the brain.
Without a well-defined concept and general agreement on specific diagnostic categories, many patients with functional disorders remain undetected and are not offered adequate treatment [ 8].
Although the modern RT techniques can prevent many cases of acute and late toxicity, many functional deficits, including progressive disorders of memory, attention and executive functions, are still present and have a clearly negative impact on the QoL of long-term survivors.
For many conditions, including pain syndromes, functional disorders, sexual dysfunction, emotional function and insomnia, PROs provide the only reasonable strategy for evaluating treatment impact.
That is the most widely known of these functional disorders, but there are many others.
Patients with IBS often have at least one co-morbid somatic complaint and many IBS patients meet diagnostic criteria for other functional disorders [ 2, 3].
Interaction or binding while remaining primarily disordered is highly unusual, as many functional IDPs are believed to adopt significant secondary structure formation upon interaction (Wright and Dyson, 2009; Uversky and Dunker, 2013), which we do not see here.
