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Furthermore, genes that were not defined as significantly differentially expressed may encode proteins with many interacting partners.
This analysis indicate that: a) genes represented by network hubs may exhibit weak co-expression with the genes encoding their interacting protein partners; and b) genes that were not defined as significantly differentially-expressed in the gene expression data analysis may encode proteins with many interacting partners.
However, a few of the bait proteins failed to identify many interacting partners (15).
Alpha-actinins are important cytoskeletal proteins with multiple roles and many interacting partners.
Our hypothesis does not contradict the complexity hypothesis which proposes that genes have different probabilities of being transferred depending on how many interacting partners their products have in the cell [ 50].
Figure 3b illustrates that the percentage of low-degree genes with EDI around zero was much higher than the percentage of high-degree genes, because the high-degree genes had many interacting partners with different functions and expression levels, whereas low-degree genes had far fewer interacting partners whose functions and expression levels were more likely to be similar.
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Some researchers have sought to refine the notion of centrality by considering interaction patterns of central nodes: those that interact with many interaction partners simultaneously are called "party" hubs whilst those that interact with a few of their partners at a time are called "date" hubs [ 128].
Using this measure, interactions between proteins with many different interacting partners (i.e., frequent interactors) have a high probability of occurring by random chance, indicating either promiscuous or strongly context-dependent interactions.
This measure allows us to observe a decreasing trend of s(k) with k (Fig. 3b) as a power-law, suggesting that domains with many interaction partners only occasionally interact with each partner.
A node with a high degree centrality is important, since it has many direct interacting partners.
It remains to be seen how TDP-43, which has many potential interacting partners, stabilizes some transcripts and decreases others.
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many interacting locales
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