Perin PM, Haid S, Brown RJP, Doerrbecker J, Schulze K, Zeilinger C, et al. Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.
They could do so in an antigen-specific manner, by targeting cells that harbor latent virus, and thus amplify the autoimmune joint disease [ 79].
External beam radiotherapy itself can be used in a focal manner by targeting radiation delivery to specific areas of the prostate.
From a theoretical perspective, the intranasal delivery route for pharmacological agents may provide a means to modulate CSF outflow in a non-invasive manner by targeting the lymphatic vasculature at the cribriform plate.
Since some transcription factors fail to recognize the methylated versions of their cognate binding sequences, it is formally possible that the cell uses DNA methylation in a sharply focused manner by targeting at a particular CpG site to regulate gene expression.
FBXO28 and HECTH9/HUWE1 seem to operate in a similar manner by targeting specific lysines in the C-terminal part of MYC, in the case of HECTH9 through lysine 63-linked ubiquitin chains, which enhance recruitment of p300 to MYC (Adhikary et al, 2005).
