Sentence examples for malignant state of from inspiring English sources

These wavelet filtered images along with FLAIR and T2 weighted images have been utilized as the features to unsupervised neural network – self organizing maps (SOM) – to segment the tumor, edema, necrosis, CSF and normal tissue and grade the malignant state of the tumor.

On the other hand, although exogenous expression of AEG-1 could increase both AURKA and Akt expression levels the simultaneous use of AURKA inhibitor Tozasertib blocked AEG-1's role of up-regulation of Akt expression in ECV304 cells, suggesting that AURKA might be a key mediator of AEG-1 in regulating Akt activation, and a key effector of AEG-1 in maintaining the malignant state of AML.

Hence, we concluded that Stat5, but not Stat3, is required for the maintenance of the malignant state of transformed lymphoid leukaemic cells in vitro.

This is in line with cell line studies where depletion of HSF1 reduces the malignant state of the cell regardless of ER status (Dai et al, 2007).

A study of ovarian tumors showed a direct correlation between serum levels, intracellular expression of SAA4 and malignant state of the epithelial cells [ 36].

The expression levels of MCT1 in association with GLUT1 could potentially be used as determinants of the malignant state of colonic tissue.

Considering that the incidence of large clones increases with disease progression from the healthy AC state to the malignant states of smoldering, chronic, or acute [ 22, 46], an accurate measurement of clone size - particularly large clones - is of great clinical significance.

The beneficial role of retinoic acid is generally attributed to a reversal of the malignant state through differentiation of the tumour cells into more mature ganglion-like cells (Matthay et al, 1999; Reynolds and Lemons, 2001).

Cell cycle dysregulation is a hallmark of the malignant state, and the function of genetic variation in cell cycle genes, including in ovarian cancer, has been reported in a number of studies (Gayther et al, 2007; Goode et al, 2009); this study extends the prior findings by the inclusion of an additional 26 and 28 additional genes, respectively.

In a malignant state, the activation of MMP-2 and -9 by MMP-7 may have an important function, and lead to increased invasiveness (Wang et al. 2005, 2006).

Cancer, Galen proposed, was a result of a systemic malignant state, an internal overdose of black bile.