In accordance with data reported in literature and discussed in this review, we also detected by immunohistochemistry the expression of HIF-1α in malignant melanoma, with a trend of higher expression in melanoma cells vs. benign nevi (Fig. 1).
This study suggested a general overall trend of increased frequency of malignant lymphoma from the late '80s to the mid '90s [36].
In these studies, we observed an identical trend of reduced expression in malignant glands but intact expression in benign glands.
Benign lesions in current study tended to have a lower and negative S value than malignant lesions because the former had a trend of decreasing SUV max with time.
Likewise, it seems that malignant transformation appears in parallel to an upward trend of ST6Gal I activity, since transitional tissue activity values are intermediate between those of healthy and tumour ones.
Total FOXM1 mRNA expression was low in normal mucosa whilst a trend of progressive increase in expression from premalignant to malignant tissues was detected.
There was a significant positive linear trend of increasing categories of radon concentrations with both COPD and non-malignant respiratory mortality (p<0.05).
Further study is needed to clarify the trend of lifestyle habits following diagnosis of OPMDs, and the roles of intervention in the malignant process of OPMDs.
Immunohistochemical analysis of the tongue infiltrating cells, revealed a general trend of increase in the proportion of T cells, B cells, and macrophages as the epithelial lesions changed towards a more malignant phenotype.
Change the trend of life.
