Sentence examples for malignant development of from inspiring English sources

We further suggest that the loss of the interaction with CDC6 or with additional client proteins could provide one route through which TTC4 could influence malignant development of cells.

However, there is little information about the malignant development of GISTs.

In addition, ZnR/GPR39 overexpression was detected in specimens of human ESCC and associated to the malignant development of this carcinoma, but the role of Zn2+ as the ligand of ZnR/GPR39 that promotes these tumorigenic processes remained elusive.

In our study, further IHC analysis confirmed that there was significant difference in malignant and benign pheochromocytomas, which indicated that ERBB-2 oncogene may be an important gene in the malignant development of pheochromocytomas.

Despite Cx26 has been considered as a potential tumor suppressor or chemotherapy sensitizer in some types of tumors, Ito et al. found that Cx26 helps lung squamous cell carcinoma (SCC, one histological type of NSCLC), acquire aggressive phenotypes, lymph node metastasis, and poor prognosis, indicating that a potential role of Cx26 on the malignant development of SCC.

Most recently, an examination of the relationships among MUC4 promoter methylation, pancreatic cancer progression, and MUC4 mRNA expression in clinical tissue samples led to the suggestion that aberrant MUC4 promoter hypomethylation may be involved in pancreatic carcinogenesis and malignant development of pancreatic ductal adenocarcinoma (Zhu et al. 2010).

The paper of Richter et al. [ 8] suggested several specific chromosomal changes that may have significance for the malignant development independent of general CI.

The hitherto best known molecular event predictive of advanced malignant development is the loss of p53 function, which is found in the majority of progressed bladder cancers and, notably, in CIS [ 4, 5].

This process is progressively inactivated during malignant development and loss of the capacity for apoptosis is a hallmark of malignant cells.

Given these findings, we hypothesized that PA28γ may be involved in malignant development and progression of OSCC and would have effect on the prognosis of this disease.

Polyp size is an important parameter because larger polyps (⩾10 mm) have a higher chance of malignant development.