Sentence examples for malignant evolution of from inspiring English sources

These data strongly suggest an active role for an ever-changing microenvironment in the malignant evolution of primary tumors, with macrophages being major players.

Poor adherence to a GFD, HLA-DQ2 homozygosity, and late diagnosis of CD are recognized as risk factors for malignant evolution of CD.

This type of genome instability greatly facilitates deletion and amplification of genes and, as a result, the malignant evolution of (pre-) malignant cells.

We find that cell turnover rate increases with decreasing androgen levels, which may increase the rate of mutation and malignant evolution.

As such, they appear to represent a defining early genomic lesion in the pathogenesis of diffuse glioma variants exhibiting step-wise malignant evolution.

Owing to this rapid and clinically malignant evolution in 6 months, we judged that the clinical behaviour of the tumour was more compatible with a high-grade glioma.

A drop in cerebral perfusion of more 66% is related to a likely malignant evolution [ 9].

Serial analysis of gene expression (SAGE) was employed to generate a comprehensive global gene expression profile of the major changes occurring during breast cancer malignant evolution.

Instead, activated wildtype p53 merely holds some of these oncogenic clones in stasis, suppressing their further malignant evolution only as long as p53 remains functional.

Here, the main problem is the late diagnosis of pancreatic cancer, which gives cancer cells enough time for malignant evolution.

However, there are still serious concerns for an increased risk of malignant transformation of genital LS due to local immunosuppression by long-term use of TCIs in a disease with an intrinsic potential for malignant evolution [ 31, 95].