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Exact(6)
This large protein shows major sequence variation, which has previously been described in detail [ 70, 72].
Major sequence variation was seen in the central region of this gene; what impact this may have on virulence is unknown.
The repetitive domain is rich in glutamine and proline, which is the major sequence variation that discriminates the different γ-gliadins.
Whereas heritability calculated from family and twin studies is in the range of 80 90%, linkage and genome wide association studies have so far been unsuccessful in identifying major sequence variation.
Similarly, major sequence variation is present in four monocot sequences from class C1, which is consistent with their grouping in a separate branch in the phylogenetic tree (Fig. 7 and Fig. 8).
This cluster and the DNA-binding site for the quorum-sensing regulator AbaR was identified in all seven virulent strains, however, there is major sequence variation in other parts of the upstream region (data not shown), which could result in differential repression by H-NS.
Similar(54)
A first major study investigated sequence variation of 25% of the species of North American breeding birds (260 species) [9].
Based on earlier observations on the major effect of sequence variation of PCSK9 gene on plasma LDL cholesterol concentrations and coronary heart disease risk and the result of the current study, PCSK9 seems to be an interesting new target molecule for the development of new antiatherogenic therapies.
Analysis of monomers from two different CRM1TR loci shows that gene conversion is the major cause of sequence variation.
Also, there can be major problems with extensive sequence variation among individuals and/or AT-richness (in some regions of the mt genome) [ 12, 13], preventing accurate sequence determination.
Therefore, the small but significant expression difference detected between the expressed genes that are strongly bound and weakly bound by the MSL complex did not have any major correlation on the sequence variation observed between the two groups.
Related(20)
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