Sentence examples for major negative feedback from inspiring English sources

It is therefore likely that the PD-1/PD-L1 signaling pathway is a major negative feedback regulator of antigen responsiveness (Okazaki et al., 2013; Honda et al., 2014).

EIN3 binding also controlled a multitude of downstream transcriptional cascades, including a major negative feedback loop.

The observation that competition proceeds similarly after eliminating a major negative feedback pathway suggests that negative feedback does not greatly affect the competition process in yeast cells.

Therefore, MDM2 induction in response to p53 is the major negative feedback loop aimed at blocking p53 proapoptotic function and thus allowing cell survival (Malaguarnera et al, 2007).

Interestingly, TNF-α effectively induces IL-10 synthesis in monocytes, which represents the major negative feedback to its own production [ 12].

Mutants in which the GEF is nonphosphorylatable (CDC2438A) largely short-circuit the major negative feedback mechanism, although a slower negative feedback may also occur via Cdc42-directed GAPs (Kuo et al., 2014; Okada et al., 2013).

Each gene undergoes alternate splicing to generate TRα1, TRα2, TRβ1 and TRβ2 isoforms, each with differing tissue distributions (e.g. TRα1 is the predominant isoform in the central nervous system, myocardium, colon and skeletal muscle; TRβ1 is highly expressed in the liver and kidney; TRβ2 plays a major role in negative feedback regulation at the level of the hypothalamus and pituitary) [6].

BMPs play an important role during all stages of embryonic development, and although only two major signaling pathways have been characterized (p38 and Smad pathways), the BMP signaling is complex and includes cross-talk with other major signaling pathways and negative feedback mechanisms [34], [48], [49].

Indeed, modulation of Smad stability (degradation via the ubiquitin proteasome pathway) plays a major role in the negative feedback.

Although GABA does not seem to be the major neurotransmitter that mediates the negative feedback signal to cones [55], changes in GABA will lead to changes in membrane conductance, membrane potential of cones and horizontal cells and in changes in receptive field size of horizontal cells [56].

These are complex effects, but the modelling does suggest that while "stress" inputs may reduce over time hormone negative feedback is a major factor reducing hormone responses.