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The compensation schemes exploit a single Miller capacitor and an active feedback to form the main negative feedback loops for pole splitting and two feedforward paths.
The main negative feedback is the energy which the Earth's surface radiates into space as infrared radiation.
MDM2, as transcriptional target of p53, is the main negative feedback regulator of p53.
These findings show that USP2 binds PER1 directly and indicate that the interaction of USP2 with the other clock proteins is indirect and possibly occurring within a complex that contains components known to participate in the main negative feedback loop of the circadian clock, including PER1.
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We develop two models capturing the main aspects of the negative feedback loop for stem cell regulation.
The organization of any self-organized phenomenon relies on four fundamental main pillars: (1) positive feedback, (2) negative feedback, (3) random fluctuations, and (4) repeated interactions among individuals [18, 20].
One of the main effects of FGF19 is the negative feedback regulation of BA synthesis, and, for this to be achieved, FGF19 transcripts must be translated into protein and released into the portal circulation.
Second, in contrast to the main variable, which is almost always used with a negative feedback, the auxiliary variable is often used with a positive feedback.
The main area of concern raised by students was with providing negative feedback to peers and the associated social discomfort.
It includes only the negative feedback via IκBα, which is known to be a main regulator in the canonical NF-κB pathway [ 17].
The main point seems to be that without anti-inflammatory responses acting as a negative feedback, the inflammatory response, which has built-in positive feedbacks, will proceed unchecked.
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