Sentence examples for major molecular subtypes from inspiring English sources

Breast cancer exhibits clinical and molecular heterogeneity, where expression profiling studies have identified five major molecular subtypes.

For a further understanding of the clinical relevance of IL-25, we examined IL-25 expression in all the four major molecular subtypes of human breast tumors, including Luminal A, Luminal B, Triple negative/basal-like, and HER2-enriched types, by immunohistochemical analysis.

Biologic therapies are shaped by the three major molecular subtypes of breast cancer, classified according to the receptors present on (or absent from) the outside of cancer cells.

Colorectal cancers (CRCs) have been classified into two major molecular subtypes: CIN and MSI (for "microsatellite instability", also called MIN).

These crude subtypes were refined by recent gene expression microarray studies, which clustered breast tumors into five major molecular subtypes [10], [11].

The epitypes adhere to the two major molecular subtypes of UC.

Gene expression analysis indicates that the major CRC molecular subtypes are represented.

PAM50, unlike signatures trained around outcome, was developed as a biological classifier of the major intrinsic molecular subtypes of breast cancer [ 12].

Hierarchical clustering analysis of this data set using the ~1,900 intrinsic gene list of Parker et al. [ 9] identified the major intrinsic molecular subtypes, including the claudin-low subtype.

Based on the differential expression of various genes, breast cancer has been categorised into five major distinct molecular subtypes with prognostic significance: luminal A; luminal B; overexpression of HER2; also known as ErbB2; breast-like; and basal-like/triple negative [ 69].

The molecular subclassification of the xenografts was determined based on distinct variation in gene expression pattern of 500 'intrinsic' genes, characteristic for five major molecular breast cancer subtypes.