Sentence examples for major genetic subtypes from inspiring English sources

High resolution aCGH analysis was carried out on all 145 primary neuroblastoma tumours in order to identify DNA copy number alterations and to classify the tumors into major genetic subtypes (MYCN amplified, chromosome 11q loss etc).

Karyotyping and FISH technique have shown that there are two major genetic subtypes in MM.

Next we investigated the identity of microRNAs associated with the major genetic subtypes of MM.

Our results confirm that there are two distinct whole-genome profiles reflecting major genetic subtypes in MM.

Recently, amongst unfavorable NB tumours, two major genetic subtypes have been described: advanced stage NB without MYCN amplification, with high 11q LOH directly associated with 14q deletion, but inversely correlated with tumours with MYCN amplification and 1p36 allelic loss [ 46, 47].

Sequence analysis of several isolates has identified 2 major genetic lineages (subtypes A and B) that can be divided into subgroups A1, A2, B1, and B2 (6, 7 ).

Breast cancer is a heterogeneous disease with four major genetic-signature subtypes [ 1].

Here we have employed quantitative, image registration-based DTI methods to demonstrate profiles of white matter tract damage in a large cohort of patients with bvFTD, representing the major genetic and sporadic disease subtypes.

Analyses of recurrent patterns of somatically acquired DNA copy number alterations resulted in the delineation of three major genetic subgroups with predictive tumour behaviour (subtype 1, 2A and 2B), of which subtype 2A NB represents an aggressive subgroup of metastatic NB [ 5, 6] characterised by loss of 11q, gain of 17q and a normal MYCN copy number status [ 6].

160, 167 These appear to be similarly or more variable in their expression and less penetrant with respect to schizophrenia, or indeed any major phenotype, than 22q11.2 deletions and the five emerging genetic subtypes.

Recently, large scale efforts have been made to identify the major genetic and epigenetic alterations and to define important molecular subtypes in GBM and lower grade gliomas [ 30, 43, 41].