Sentence examples for main molecular subtypes from inspiring English sources

Mouradov, D. et al. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Selected tumors were representative of all histological grades (10, 3 and 7 tumors of grade I, II and III, respectively), and main molecular subtypes (12 ER+, 3 HER2+ and 3 triple negative tumors).

Sequence analysis of the highly variable open reading frame (ORF K1 of HHV-8 has enabled the identification of 5 main molecular subtypes, A E (1 ).

These strains had env nucleotide sequences ≈99% similar to each other and diverging from the main molecular subtypes of HTLV-1 by 6%to9%9%.

Finally, the sequences of these new strains diverged from those of HTLV-1 strains from the 3 other main molecular subtypes (A, B, D) by 6%to9%9%.

These models were selected because they recapitulate the genetics and drug sensitivity of the main molecular subtypes of human breast cancer [ 42].

At present this event defines the main molecular subtype of prostate cancer.

Curcumin cell death effect was tested in a large collection of HMCLs (n=29) encompassing the main molecular myeloma subtypes; after 24 h treatment cell death was determined by Apo2.7 staining followed by FACS analysis.

HHV-8 K1 gene characterization of KS tumor biopsy samples demonstrated high molecular genotype diversity, including 4 of the 5 main known molecular subtypes.

In this study, we used gene expression data to classify multiple independent cohorts of patients from cooperative group trials and large multi-institution data sets into the main intrinsic molecular subtypes of breast cancer and then we evaluated the ability of various published gene expression profiles to predict response and/or survival following chemotherapy in TNBC and/or BLBC.

Over the years, studies based on global gene expression analyses have identified five main intrinsic molecular subtypes of breast cancer known as luminal A, luminal B, HER2 enriched, basal like and claudin low (Perou et al, 2000; Sorlie et al, 2001; Prat et al, 2010, 2013a, 2013b; Prat and Perou, 2011).