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Conclusion: Collectively, the data indicate that pregnancy is characterized by the presence of soluble HLA-G circulating in maternal blood and strongly suggest that the major isoform is soluble HLA-G2.

Its major isoform is the [α1 V ]2α2 V) heterotrimer, composed of two proα1-chains and one proα2-chain [1], [2].

(1) Humans possess three isoforms of VDAC channels; to date VDAC1, the major isoform, is the best characterized.

A major isoform is defined as the transcript with the highest expression value within a given sample.

If the major isoform is conserved across bacterial species, this E. coli platform could even be applied to those as distant as M. tuberculosis.

16 The major isoform is comprised of 485 amino acids and has a carboxy- terminal "tail," which is necessary for its localization to the endoplasmic reticulum where it encounters a variety of aldehyde substrates.

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The purified and re-chromatographed major isoform was deglycosylated to remove covalently bound carbohydrates.

In GAS, the major isoform was MHCIId (35.6 %), expressed together with smaller amounts of IIb (28.1 %).

If the major isoform was not the same in each replicate then that gene was not included in further analyses.

In 4,777 genes (54%) we found that the same major isoform was expressed across all the samples where the gene is expressed.

In the canonical NF-κB pathway, inflammatory cues engage NEMO-IKK2 (NEMO-IKKβ) kinase complex to phosphorylate inhibitory IκB proteins, the major isoform being IκBα, bound to the cytoplasmic RelA p50 NF-κB dimers.

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