Sentence examples for maintaining barrier integrity from inspiring English sources

Consistent with this, enhancement of endothelial BMPR2 signaling by BMP9 is highly effective in preventing apoptosis and maintaining barrier integrity of pulmonary arterial endothelial cells (PAECs) from PAH patients bearing BMPR2 mutations.

Accordingly, maintaining barrier integrity represents a key issue in the defense capacity of the epithelium [3].

However, because these studies have used germline knockout of TLR4, TLR2 and MyD88, it is not clear whether epithelial cell- or immune cell-derived signaling is responsible for maintaining barrier integrity.

This can lead to systemic infections, sepsis, and multiple organ failure, which underscores the importance of maintaining barrier integrity (Choudhry et al. 2000, 2004; Napolitano et al. 1995).

Since TIMAP is involved in the regulation of EC barrier function [ 4], RACK1 should also be regarded as a participant in maintaining barrier integrity, through the regulation of TIMAP prenylation.

Altogether, these observations strongly suggest that nPKC-selective activation generally contributes to maintaining barrier integrity, whereas cPKC activation has the opposite effect, both in polarized epithelium and endothelium (Table 1).

The crypt-villus axis (see Glossary) allows constant regeneration of cells by differentiation and migration of cryptic stem cells to maintain barrier integrity.

Similar to our previous observations, we expect that during aglycemic conditions, the endothelium attempts to protect and maintain barrier integrity as a primary event in the attenuating brain edema during cerebral ischemia [ 24].

During aglycemic cell stress, lack of glucose stimulates endothelium to conserve their energy sources by shutting down the cellular metabolic process and diverting the cellular energy pools to maintain barrier integrity and in endothelial reparative processes.

The use of CO in patients undergoing bone marrow transplantation or in patients treated with chemoablative therapies may show great beneficial effects with a CO treatment regimen that enables efficient and appropriate regeneration and differentiation of myeloid cells to maintain barrier integrity of the host and ensure robust defense systems.

The integrity of the intestinal epithelium is essential for maintaining barrier function, nutrient uptake, metabolic homeostasis, and hence, organismal health and survival.