Sentence examples for maintaining chromatin integrity from inspiring English sources

This evidently requires some mechanism for maintaining chromatin integrity.

A role of H3K36me3 in maintaining chromatin integrity was recently disclosed by the finding that the DNA mismatch repair (MMR) protein MutSα binds H3K36me3 and that SETD2 is necessary for human DNA MMR, a mechanism that corrects mismatches generated during DNA replication (Li et al., 2013).

This highlights the potential importance of histone H1 in maintaining chromatin integrity, and suggests two possible functions of H1 variants: a general one redundant among H1 variants and related to the formation of higher order chromatin, and an individual, gene-specific one.

Grande, M. et al. Crosstalk between Nap1 protein and Cds1 checkpoint kinase to maintain chromatin integrity.

We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity.

Ray-Gallet, D. et al. Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.

In vitro and in vivo studies in budding yeast now reveal that the Isw1b chromatin remodeler is recruited by H3K36 methylation to open reading frames, where it acts in conjunction with a second remodeler to prevent histone exchange and maintain chromatin integrity during transcription elongation.

H3.3 is found decorated with various histone modifications that regulate transcription and maintain chromatin integrity.

The cell engages different co-transcriptional mechanisms to maintain chromatin integrity over transcribed genes.

Therefore, the protein encoded by this histone gene may function to maintain chromatin integrity in immature neurons or might be involved with transcription or DNA repair.

It has been suggested that polyadenylated histone variants are required in these non-replicating cells to maintain chromatin integrity [ 7, 39].