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It takes an essential role in maintaining muscle integrity in flies [46].
Taken together, we conclude that Drosophila C3G is a Rap1-specific GEF with important functions in maintaining muscle integrity during larval stages.
The use of animal model systems has led to the clarification of the roles of specific gene products in maintaining muscle integrity and function (reviewed in [4]), however, the regulation of this complex is largely unknown.
In conclusion, we propose that C3G is an accessory component of the Drosophila musculature, essential for the proper localization of integrins at muscle-muscle and muscle-epidermis attachment sites and important for maintaining muscle integrity during larval stages.
It is also possible that Importin-α2 is involved in maintaining muscle integrity; mutations in dystroglycan and POMT1 that affect larval muscle integrity also display patterning defects akin to and at similar frequencies to those of the importin-α2 mutants [62].
Indeed, many of the target genes downregulated via FoxO play critical roles in maintaining muscle integrity, fiber size and contractile function.
Similar(48)
This study indeed supports oxidative changes in muscle during aging that may be both inductive of sarcopenia and a compensatory mechanism to maintain muscle integrity.
In conclusion, a combined treatment with apoptosis inhibitors and mini-agrin increases the regeneration efficiency in dy W / dy W muscles and, thereby, maintains muscle integrity.
Furthermore, the changes in ROS and antioxidant activity after sarcopenia was first evident gives some evidence for a compensatory mechanism, in response to insult, in order to maintain muscle integrity.
Being an integral member of the link between the cytoskeleton and the extracellular matrix, dystrophin is hypothesized to have a role in stabilizing the sarcolemma (the muscle cell membrane) and maintaining muscle fiber integrity during muscle contraction [ 29- 31].
Therefore, the up-regulation of HSP70 (spot 4) in broiler muscle fed E. faecium was potentially useful for maintaining muscle cell integrity and repairing denatured proteins, such as desmin and sarcoplasmic proteins.
More suggestions(15)
maintaining bone integrity
maintaining grid integrity
maintaining muscle glycogen
maintaining muscle mass
maintaining barrier integrity
maintaining muscle tone
maintaining muscle function
maintaining cuticle integrity
maintaining muscle strength
maintaining muscle health
maintaining warehouse integrity
maintaining muscle size
maintaining chromatin integrity
maintaining muscle fiber
maintaining muscle structure
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