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Therefore cancer cells also utilize the DNA repair machinery to process DNA damaging lesions and maintain cellular survival.
Many earlier studies have shown that resistant genotypes have efficient mechanisms for stress perception and enhanced expression of defence-responsive genes, which maintain cellular survival and recovery [ 31].
It may thus be possible that INPP1 knockdown and subsequent glycolytic impairments may upregulate AKT and MAPK signaling pathways to maintain cellular survival.
Many elements of this pathway are regulated by the activities of HSP 70 and 90 to help maintain cellular survival following death receptor ligation.
In these cell types, oxygen consumption under condition of low oxygen concentration is reduced to maintain cellular survival without an increase in anaerobic energy production.
Similar(55)
Further, their survival is supported by both the heat shock pathway and UPR because these molecular processes are essential for Ig folding and efficient protein degradation via the proteosome and autophagy, which both regulate intracellular proteotoxic stress maintaining cellular survival.
Autophagy, a lysosomal pathway for intracellular bulk degradation of cytoplasmic macromolecules and organelles, has a key role to maintain cellular homeostasis and survival.
Inhibition of PI3K/mTOR signaling is known to induce autophagy, a process in which cytoplasmic contents are degraded in order to maintain cellular energy balance and survival [ 16, 20].
Autophagy is an important cellular process that controls cells in a normal homeostatic state by recycling nutrients to maintain cellular energy levels for cell survival via the turnover of proteins and damaged organelles.
Autophagy is a highly conserved system in eukaryotes for the bulk degradation of obsolete organelles or proteins to maintain cellular homeostasis or to struggle for the survival from starvation.
Cells employ autophagy to maintain cellular metabolism under starvation conditions and to remove damaged organelles under stress conditions to improve survival.
Related(20)
sustain cellular survival
maintain cellular viability
maintain neuronal survival
maintain maximal survival
maintain cellular water
maintain high survival
maintain organismal survival
maintain cellular morphology
maintain cellular energy
maintain cellular architecture
maintain glial survival
maintain cellular metabolism
maintain cellular homoeostasis
maintain cellular homeostasis
maintain cellular renovation
maintain rudimentary survival
maintain cellular polarity
maintain cellular iron
maintain biological survival
maintain cellular protein
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