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Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton.
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Here, we describe how nesprins are necessary in maintaining cellular architecture by acting as essential scaffolds and linkers at both the NE and other sub-cellular domains.
Cell cell adhesion directs cytoskeletal dynamics to establish and maintain cellular polarity, which ultimately determines accurate tissue architecture (Mays et al. 1995; Nejsum and Nelson 2007; Desai et al. 2009).
All our tissues including the skin need water to maintain cellular functions.
Degraded components also need to be replaced by newly synthesized molecules in order to maintain the cellular architecture.
HCA also maintained cellular viability, preventing stretch-induced cell death.
Protein protein interactions (PPIs) are vital to maintaining cellular homeostasis.
Aquaporins (AQPs) are primarily involved in maintaining cellular water homeostasis.
Autophagy is of great significance in maintaining cellular homeostasis.
This highly evolved microenvironment maintains cellular signaling.
Autophagy maintains cellular homeostasis in normal tissue.
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