The main pathological characteristic of PD is cell death in the substantia nigra and, more specifically, the ventral (front) part of the pars compacta, affecting up to 70% of the cells by the time death occurs.
The main pathological characteristic of BEN kidney is interstitial fibrosis.
Hereditary spastic paraplegias (HSP) are rare neurodegenerative diseases sharing the degeneration of the corticospinal tracts as the main pathological characteristic.
Although there are some reports that Lewy bodies are present in the cells of these patients, the main pathological characteristic of mutant parkin carriers is the degeneration of substantia nigra dopaminergic neurons (Lees et al., 2009; Hardy, 2010).
The main pathological characteristic is suspected to be an axonopathy of the longest corticospinal tracts and ascending dorsal columns, but there are only rare neuropathological studies on spinal cord tissue of HSP patients to clearly define structural changes relevant to the disease (2– 4).
Main clinic pathological characteristics of the population are presented in Table 1.
The main clinico-pathological characteristics of the population are summarized in Table 1.
