Sentence examples for main pathological feature from inspiring English sources

Over 160 mutations in superoxide dismutase 1 (SOD1) are associated with familial amyotrophic lateral sclerosis (fALS), where the main pathological feature is deposition of SOD1 into proteinaceous cytoplasmic inclusions.

Although there are some controversies about polyglutamine aggregate and cellular toxicity, aggregate formation is a main pathological feature and detecting modulators of aggregation may help our understanding of the pathological process of Huntington disease.

Vascular remodelling is the main pathological feature in PH and is mediated via vasoactive molecules [ 4].

The main pathological feature of SLE is the overproduction of circulating antinuclear proteins and anti-DNA autoantibodies.

While all tissues involving the synovial joint are affected, the degeneration of articular cartilage is the main pathological feature in this disease.

Corticospinal tract axonopathy is also the main pathological feature of a group of genetic disorders termed the hereditary spastic paraplegias (HSPs) [3,4].

The main pathological features in the Alzheimer's brain are progressive depositions of amyloid protein plaques among nerve cells, and neurofibrillary tangles within the nerve cells.

Recently, we have shown that the main pathological features of severe PAM are reproduced in a mouse model [22] and Megnekou et al. [23] evidenced that pregnant mice accumulated specific antibodies against recrudescent parasite.

The aggregation and deposition of proteins is one of the main pathological features of AD [ 3].

Table 1 gives an overview of the patient demographics and main pathological features.

One of the main pathological features of rheumatoid arthritis is marked destruction of cartilage [ 1].