Sentence examples for main pathological hallmarks from inspiring English sources
Together, our studies highlight the key role of mitochondria in AD pathogenesis, and the close interrelationship of this organelle and the two main pathological hallmarks of this disease.
The two main pathological hallmarks of PSP include globose-type NFTs and tuft-shaped astrocytes, while other neurodegenerative tauopathies display different histological tau features [ 1, 11, 12].
Overexpression of DSH-1 and DSH-2 has been shown to inhibit GSK-3β mediated phosphorylation of tau protein, thus preventing the formation of NFTs (one of the main pathological hallmarks of AD), and increasing neuroprotection [ 44].
The main pathological hallmarks of AD are two types of protein deposits, amyloid plaques and neurofibrillary tangles and the degeneration of cholinergic neurons in the basal forebrain and the associated loss of cholinergic neurotransmission in the cerebral cortex and other areas.
Given that Lewy body deposition is the main pathological hallmark of dopaminergic neurons in PD patients.
Misfolded α-synuclein (aSyn) is the main protein component of Lewy bodies (LBs) – the primary pathological hallmark of PD – and aSyn has also been genetically linked to both familial and idiopathic forms of PD.
Thus, a growing body of literature suggests that synaptic loss and dysfunction and network disruptions, rather than conventional pathological hallmarks, are main players in the development of cognitive decline in AD.
However, none of the current neurotoxin-based models recapitulates the main clinical features of the disease or the pathological hallmarks, such as dopamine (DA) neuron specificity of degeneration and Lewy body formation, which limits the use of these models in PD research.
The pathological hallmarks of PD are neuronal inclusions termed Lewy bodies and Lewy neurites (LN) whose main component is aggregated and phosphorylated alpha-synuclein [12], [13], [14].
These pathological hallmarks are frequently observed in human-excised tissue.
Aβ plaque in brain is one of the pathological hallmarks of AD [61, 62].
