Sentence examples for main host cell from inspiring English sources

The present model studied the interactions among the HIV-1 virus, its main host cell (activated CD4+ T cells), and a therapeutic engineered virus in an in vivo context; and it examined the conditions for controlling the pathogen.

To date, no study has assessed whether extracts from P. angulata's root affect Leishmania parasites, the main host cell (macrophage), or determined the presence of physalins in the root extract.

Finally, by exploiting these two experimental models, we identified the role of the stress sensor growth arrest and DNA damage 45 α (Gadd45 α) as a main host cell player in triggering the death of the cells infected by Shigella.

Macrophages are the main host cell for Leishmania protozoa, so it is important to know the toxicity of the methanolic extract and hexane fraction of L. pubescens on these cells as well as their selectivity on the intracellular parasites.

Since further analysis is needed to better understand this immune phenomenon between NTM and MΦ, we conducted the present study using different NTM species to elucidate (1) their ability to infect, persist, and proliferate inside their main host cell, the macrophage; (2) their effect on the initial innate immune response of macrophages.

The main host cells infected by HTLV-1 in vivo are CD4+ and CD8+ T cells [5], [8] [10].

Here we sought to use microarray technology to decipher simultaneously transcriptional changes in a human pathogen of primary public health importance, Mycobacterium tuberculosis, and in its main host cells, macrophages (Mφs) and dendritic cells (DCs) throughout infection.

MMP-8 is expressed by many types of cells [ 9, 10] and known to be the main host cell-derived collagenase that contributes significantly to tissue destruction and remodeling events in inflammatory periodontal diseases [ 11- 14].

Macrophages (MΦ), the main host cells for the intracellular parasite Leishmania, are crucial for the outcome of disease: depending on the expression of two inducible enzymes, NO synthase 2 and arginase, MΦ can either kill the parasites or promote their growth.

As outlined in Additional file 4: Table S3, cpL1_0338 and cpL1_0441, were both identified as effectors of the chlamydial Type 3 Secretion System (T3SS), a system of structural, chaperone and secreted effector proteins with its main function in host cell manipulation and subversion of the host cellular processes [ 47, 48].

The main host defense against listeriosis is the cell mediated immunity, and therefore individuals with T-cell dysfunction seem to be particularly at risk of contracting the disease.