loss of esc

USAGE SUMMARY

The phrase "loss of esc" is not correct in standard written English as it lacks clarity and context.
It may be used in specific technical or industry-related discussions, but it requires additional context to be fully understood. Example: "The loss of esc during the operation led to a significant decrease in performance."

⚠ May contain grammatical issues

Science

Human-verified examples from authoritative sources

Exact Expressions

10 human-written examples

The extent of the knockdown was validated by western blot and qRT-PCR and resulted in a clear and reproducible phenotype with a higher proportion of ESC colonies displaying a flattened or spread morphology indicative of a loss of ESC characteristics.

Cell Stem Cell

Depletion of Ddb1 resulted in loss of ESC self-renewal and pluripotency (Buckley et al., 2012).

eLife

Upon transfection with mimics for miR-125b, miR-181a, or miR-181b, we observed a loss of ESC characteristics.

Cell Stem Cell

Efficient loss of ESC identity over 3 days is a time window compatible with perdurance of transient knockdown by siRNA.

Cell

Nuclear exclusion of Tfe3 in postimplantation epiblast cells appears to coincide with epithelialization prior to gastrulation and loss of ESC derivation potential (Nichols and Smith, 2011).

Cell

Among these 23 genes, we identified 8 genes whose KD induces the loss of ESC undifferentiated state even in the presence of LIF.

BMC Biology

Human-verified similar examples from authoritative sources

Similar Expressions

50 human-written examples

Contradicting studies report on whether the effect of UTX loss on ESC differentiation depends on its H3K27me3 demethylase activity.,,, Namely, male UTX KO ESCs that express a catalytic inactive or wild-type Utx protein both could rescue the induction of expression of the mesoderm genes Wnt3 and Brachyury supporting an H3K27me3-demethylase-independent H3K27me3-demethylase-independent H3K27me3-demethylase-independent

Epigenetics

Overexpression of Yap inhibits ESC differentiation and maintains stem-like properties and self-renewal even under differentiation conditions, while Yap/Taz knockdown is sufficient to result in the loss of the ESC phenotype (Varelas et al., 2008; Lian et al., 2010; Tamm et al., 2011; Beyer et al., 2013).

Protein & Cell

The consequences of Esrrb loss-of-function in ESCs has until now been limited to knockdown experiments (Ivanova et al., 2006).

Cell Stem Cell

In gene-targeting (loss-of-function) experiments, ESCs served as vehicle for the selective inactivation of genes by homologous recombination (Thomas and Capecchi 1987), which so far resulted in the creation of more than thousand "knock-out mice" with specific genetic defects.

Archives of Toxicology

Modifications in the mobility of chromatin interacting proteins are known to occur during loss of pluripotentiality of ESC [ 56].

BMC Genomics

Expert writing Tips

Best practice

When discussing "loss of esc", clearly define what "esc" refers to in your context. This will help avoid ambiguity and ensure your audience understands your meaning.

Common error

Avoid using "loss of esc" without specifying what "esc" stands for. The acronym is not universally understood, so provide context to ensure clarity.

Linguistic Context

The phrase "loss of esc" functions as a noun phrase indicating a deprivation or reduction. It describes a state where something associated with 'esc' is no longer present or has diminished. Ludwig AI reports that the phrase, while used in technical contexts, lacks clarity in standard English.

Expression frequency: Uncommon

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Wiki

0%

Ludwig's WRAP-UP

The phrase "loss of esc" refers to a state of reduction or absence associated with 'esc', most commonly in scientific research related to embryonic stem cells. Ludwig AI identifies it as lacking clarity in standard English despite its use in specialized contexts. When using this phrase, define "esc" clearly to avoid ambiguity. Consider using more descriptive alternatives such as "esc failure" or "absence of esc" for improved clarity. The phrase appears primarily in scientific publications, indicating a formal and technical register.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

esc failure

This alternative replaces "loss of" with "failure", focusing on the malfunction of ESC.

esc malfunction

This alternative uses "malfunction" to describe the improper working of ESC.

esc dysfunction

This alternative uses "dysfunction" to indicate abnormal ESC function.

esc absence

This alternative focuses on the lack of ESC, rather than its loss.

esc deficiency

This phrase highlights a shortage or inadequacy of ESC.

esc depletion

This alternative indicates a reduction in the amount of ESC.

reduction in esc

This option uses a more descriptive phrase to convey a decrease in ESC.

decrease in esc

This phrase is similar to "reduction in esc" but uses the word "decrease".

elimination of esc

This alternative suggests a complete removal of ESC.

lack of esc

This option directly states the absence of ESC.

FAQs

What does "loss of esc" mean in a scientific context?

In scientific literature, "loss of esc" often refers to the loss of embryonic stem cell characteristics or pluripotency. Consider using more explicit language like "loss of embryonic stem cell pluripotency" for clarity.

How can I rephrase "loss of esc" to be more precise?

Depending on the context, you can use "esc failure", "esc dysfunction", or "esc absence". Always ensure your wording accurately reflects the intended meaning.

Is "loss of esc" grammatically correct?

While used in some technical contexts, "loss of esc" lacks clarity in standard English. It's better to use more descriptive alternatives such as "failure of ESC" or "absence of ESC".

What is the difference between "loss of esc" and "failure of esc"?

"Loss of esc" generally implies a reduction or disappearance of ESC characteristics. "Failure of esc" suggests that the ESC is not functioning correctly. The choice depends on the specific situation being described.