Sentence examples similar to failure of esc from inspiring English sources
The low rate of chimera formation may be caused by a problem of the ESCs to integrate into the inner cell mass, and/or from failure of the incorporated ESCs to truly participate in embryo development.
The failure of CFP1-null ESCs to effectively differentiate in vitro is consistent with an important role for CFP1 in lineage commitment and perhaps relates to its capacity to bind CGIs and contribute to gene regulation [ 41].
These findings show that the failure of Dgcr8−/− ESCs to silence self-renewal upon differentiation can be overcome by promoting either EMT or apoptotic programs and suggest that let-7 silences ESC self-renewal at least partially by activating these programs.
Inducible knockout of PDCD2 in ESCs resulted in failure of entry into S phase of the cell cycle, and PDCD2 knockout embryos exhibited a significant defect in growth.
Analysis of ESC differentiation by the ePD image and PD index.
We further separated ECDs and LCDs into ones that associate with replication timing of ESC.
(E) Summary of ESC (DsRed) contribution to E4.5 embryos.
(H) Summary of ESC (DsRed) contribution to E10.5 chimeric embryos.
GI50, TGI and LC50 of ESC-2 were similar to those of ESC.
Therefore, the order of antitumor effects of ESCs was comprehensively evaluated according to the effect strength (ESC-2 had cell killing effect), effect dose (administration dose of ESC-2 was 1/3 of ESC) and the antitumor spectrum (ESC-2 had obvious inhibitory effects on 4 cell tumor lines): ESC-2 > ESC > ESC-1.
