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Exact(31)

It would be desirable, therefore, to see if mechanistic insight can be derived from the experimental paradigm reported by Hameed et al., specifically whether blockers with further specificity of the NOX- or mitochondrial pathways alter the reported outcomes.

There is no further specificity to the results in terms of which specific patients or sub-groups may have driven this difference.

Our results suggest that genomic binding of STATs is primarily determined by the cell type and further specificity is achieved in part by juxtaposed binding of cell-specific transcription factors.

Different PDEs, including PDE2-, PDE3- and PDE4-family isoforms, have been shown to be targeted to specific subcompartments either close to cAMP-production or -sensing sites, with further specificity achieved through alternative splicing (Shakur et al., 2000; Mongillo et al., 2006; Nilsson et al., 2006; Houslay, 2010).

Further specificity was incorporated by exploiting the differences in chromatographic retention from those of potential interferants.

A further specificity worth noting is that the "elimination of opposite superimpositions" can bear on an object which is not the appearing object.

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Similar(29)

Further, specificity-determining residues (Sdr) will determine that distinct classes of peptidoglycans are recognized by different PGRPs: PGRP-S2 and S3 are predicted to bind MPP-Dap type peptidoglycans [ 31].

In conclusion, this study is the first to report a non-apoptotic function of caspase-7 in osteogenesis and also demonstrates further specificities in endochondral versus intramembranous ossification.

Travel time is, arguably, the most relevant estimate of distance, but its calculation introduces further specificities, as temporal anomalies are added to the local features, further reducing its generality.

To increase further the specificity, a second step of type discrimination was used in which specific extension of 3′-termini matched oligonucleotides was performed.

Sequence-fitness landscapes identified additional mutations that further enhanced specificity.

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