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Exact(7)
As supraphysiological levels of LCA were used to stimulate esophageal cells, further research will be required using extensive stimulation assays that mimick the in vivo situation by long-term repetitive stimulations with a mix of bile acids in physiologic concentrations as recently performed [ 49].
However, extensive stimulation of ROS generation in mitochondria has been shown to be able to induce cancer cell death, and is one of the major mechanisms of action of many anticancer agents.
In brief, breaking tolerance to enable these cells to access the islets requires a remarkably extensive stimulation protocol, mimicking some of the effects of acute viral infection by repeated stimulation, immunization and TLR ligation (Figure 2A).
However, the hormone did not alter the extensive stimulation by IL-1β of IL-6 synthesis (Table 2).
This route of ATP generation is most important for refilling the PCr energy store in oxidative tissues, e.g. upon extensive stimulation of muscle contraction and thus is relevant for recovery after exhausting exercise (Quistorff et al. 1993).
During sepsis, in addition to extensive stimulation of the innate immune system and phenotypic modification of the endothelium, white blood cell activation and complement system activation leads to the release of a number of mediators or cytokines (Jean-Baptiste 2007).
Similar(53)
A greater focus on including measures of alcohol stimulant effects in human studies will be necessary to translate the extensive locomotor stimulation animal literature across species.
A clinical observation (not published) is also that during extensive photic stimulation, especially children with generalized PPRs complain of headache.
Indeed, several lines of evidence suggest that extensive inflammatory stimulation may induce EPC dysfunction in humans.
The extensive autocrine stimulation that occurs in tumors has significant implications for innovative therapeutic and biomarker strategies for leukemia.
On the other hand, considerable evidence suggests that high-grade, extensive inflammatory stimulation may have the opposite effect on circulating levels of EPCs.
Related(20)
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