Sentence examples for substantial stimulation from inspiring English sources

It is nearly impossible to extract hydrocarbon fluids from shale reservoirs without substantial stimulation of the formation, and the currently favored model is that of the multi-fractured horizontal well.

The ultra-low permeabilities, combined with the requirement of substantial stimulation to achieve commercial flow rates, have led to the descriptor of "unconventional reservoirs" for shale plays (Pitabunkate et al. 2014; Islam and Patzek 2014; Passey et al. 2010; Shabro et al. 2011).

It should be noted that at later time points during the infection, the LDLR+/+ mice exhibited a greater cytokine response than did LDLR−/− mice, and this is likely due to the 1000-fold greater bacterial burden in the control mice, leading to substantial stimulation of the host response.

Long-term treatment of mERhigh MCF-7 cells with 1 pmol/l E2 resulted in substantial stimulation of proliferation (Fig. 9).

However, many questions remain unanswered, perhaps the most notable of which is how to achieve substantial stimulation of postprandial gut endocrine secretion.

Following irradiation of the mammary gland, a substantial stimulation of D2A1 cell migration occurred at the expense of the growth of the primary tumours, which were smaller and more elongated compared with the tumours implanted in nonirradiated mammary glands.

These granules are released into the plasma upon substantial inflammatory stimulation [22] where NGAL exerts bacteriostatic effects [6] and activates neutrophil granulocytes among other functions.

Importantly, in this model, the total depletion of Treg compartment induced a substantial polyclonal stimulation of T-cell compartment but did not increase Th1 responses specific to mycobacterial antigens.

Being the location of the offices of the provincial government, Ambon island had received substantial economic stimulation activities which generated better income for most of its inhabitants.

Results suggested substantial eCO2 stimulation of photosynthesis (Luxmoore et al. 1993; Gunderson and Wullschleger 1994; Medlyn et al. 1999; Norby et al. 1999) across various woody species (e.g. in oak, yellow poplar (Gunderson et al. 1993), pine (Tissue et al. 1997), eucalypts (Ghannoum et al. 2010) and tropical seedlings (Ziska et al. 1991)).

Our initial experiments demonstrated that a steep outwardly directed transmembrane concentration gradient created by addition of intravesicular l-serine caused substantial trans-stimulation of 7.5 µM [C] l-serine influx into MVM vesicles (experiment 4b).