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The results of our published studies demonstrate proof of principle that our approach, based on multiplexed analysis of ex vivo cytokine production in response to broad stimulation, can identify profiles of immune function associated with radiographic joint damage as well as myocardial disease in patients with RA [ 10, 15].
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Furthermore, Pg antibody responses in RA patients have not been compared to those of patients with other connective tissue diseases (CTDs), such as lupus, which are associated with broad immune stimulation.
The CCT programme is also part of a broader demand stimulation strategy by SURE-P MCH, which includes recruitment of Village Health Workers to work directly in targeted communities.
Unlike with STDP, LTD or LTP should then occur to a similar extent for a broad range of stimulation protocols, such as reported for instance with repetitive TMS where LTD is associated with continuous low-frequency stimulation up to 1 Hz and LTP with interleaved or patterned high-frequency stimulation across many frequencies (5 20 Hz and iTBS) [86].
Consequently, several tissues of both transgenic mice provide rapid responses to a broad range of stimulation.
Chemosensory detection could likely benefit from this broad distribution, whereby stimulation may activate sensory fibers that extend to higher brain centers.
Systemic application of recombinant IL-12 resulted in a broad and undirected stimulation of the cellular immune system lacking antitumoral efficacy.
The ability to discriminate changes in luminance across a broad range of stimulation frequencies is characteristic feature of photopic vision in many species, including mice (Umino et al., 2008).
However, traditional versions of 1 specific technique, transcranial direct current stimulation (tDCS), stimulate broad regions of cortex with poor spatial precision.
Thus, our finding reveals that delNS1 virus induces a broader range of stimulation than single molecules do.
Here, we address those limitations by testing a broader range of stimulation parameters and by measuring learning 2 hr after training as well as during the 30-min training session.
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