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Exact(12)
They demonstrated the ability of this fullerene derivative to prevent oxidative-induced cell death without evident toxicity [34].
The results suggest that amino acid C60 derivatives have the potential to prevent oxidative stress-induced cell death without evident toxicity.
We used 60%% O2 for nonhypoxic condition because 60%% O2 does not show evident toxicity in healthy animals and is considered to be clinically safe in humans [24].
However, recent studies have shown evident toxicity of some nanoparticles to living organisms (toxicity), and their potentially negative impact on environmental ecosystems (ecotoxicity).
The test designs evaluated included: (1) two, three, or five animals per dose group (2) evident toxicity or lethality endpoints and (3) absence or presence of a one-animal sighting study.
FK866 showed no evident toxicity on renal and liver function, nor did FK866-treated mice show weight loss or increased frequency of concomitant infectious or neoplastic disease over a period of 80 days.
Similar(48)
Pharmacological parameters were examined for correlation with clinically evident toxicities.
No clinically evident cardiac toxicity was observed.
The treatment is usually limited by the cumulative absorbed dose to the kidneys, where the radiopharmaceutical is reabsorbed and retained, or by evident haematological toxicity.
The simplicity of purging an autograft with MegaFasL, its strong apoptotic effect on various hematological disorders, and the absence of evident HPC toxicity, underline the advantages of MegaFasL.
Notably, the improvement of the sh1−/− retinal defects is associated with a normal retinal architecture (supplementary Fig S9B) which further suggests that subretinal delivery of dual AAV TS and hybrid AK vectors does not induce evident retinal toxicity.
Related(19)
noticeable toxicity
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discernible toxicity
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pronounced toxicity
observed toxicity
evident ethnicity
evident today
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evident inconsistency
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