Sentence examples for prominent toxicity from inspiring English sources

To establish a satisfactory delivery system for the delivery of salinomycin (Sal), a novel, selective cancer stem cell inhibitor with prominent toxicity, gelatinase-responsive core-shell nanoparticles (NPs), were prepared by nanoprecipitation method (NR-NPs) and single emulsion method (SE-NPs).

In contrast, topotecan, a TOP1 poison and known hematopoietic suppressor, had prominent toxicity.

Peripheral sensory neuropathy is another prominent toxicity, thought to occur as a result of tubulin stabilisation disrupting the architecture of non-dividing neuronal cells.

Chlorambucil was first considered a potential treatment for CLL when early work demonstrated that lymphopenia was a prominent toxicity of the drug.

She received 1 cycle of dacarbazine, mitomycin c, and cisplatinum, with a very good response, but prominent toxicity including myelosuppression and fatigue.

Besides fatigue, the most prominent toxicity concerned liver toxicity, as shown by elevated bilirubin levels in 16 patients, including grade 3 to 4 in five patients.

Neurologic toxicities were still the most prominent toxicities; fever and hypotension were also observed in some patients.

As expected, prominent toxicities associated with docetaxel were dose-dependent grade 3-4 neutropandia and leukopaenia.

Consistently, proteinuria and increased serum creatinine levels were the most prominent toxicities identified in the formal preclinical evaluation of BMTP-11 in rodents and nonhuman primates.

Triplet regimens consisting of the combination and cisplatin or capecitabine in advanced solid tumors exhibited prominent toxicities suggesting difficulties of further developments of triplet regimens [ 28, 29].

TiO2 nanoparticles had the direct hemolytic effect in rabbit erythrocytes [14], and AgNPs showed prominent hemolytic toxicity in human blood [17].