Growth, overt toxicity, and reproductive development were evaluated at test termination.
Notably, the selective anticancer properties of these REV-ERB agonists impair glioblastoma growth in vivo and improve survival without causing overt toxicity in mice.
Intravenously injected targeted exosomes delivered Dox specifically to tumor tissues, leading to inhibition of tumor growth without overt toxicity.
In vivo, its HCl salt, 21, reduced tumor size and vascularity in xenograft and allograft murine models and was superior to docetaxel and sunitinib, without overt toxicity.
Furthermore, histological and biochemical analysis, and body weight measurement demonstrate that there is no overt toxicity of aqQDs in mice even at long-time exposure time.
Based on a minimum effect on weight gain, lack of overt toxicity to the liver, and a maximum effect on mutagenicity, a diet containing 2% comfrey root was chosen for the mutagenesis experiment (see Supplements 1 and 2).
In the current study, we administered CPF to neonatal rats on postnatal (PN) days 1-4 (1 mg/kg) or PN11-14 (5 mg/kg), treatments that were devoid of overt toxicity.
We conclude that the compounds display significant anti-tumor activity without overt toxicity.
Mice were examined daily for any signs of overt toxicity during the treatment phase as previously described [42].
Dieldrin concentrations were selected to produce serum levels representative of human background body burdens, occupational exposure, and overt toxicity.
At least in our experiments we did not observe signs of overt toxicity, albeit mice cannot be considered as a suitable model to assess toxicity of shigellae.
