Sentence examples for by phosphorylation of specific from inspiring English sources

Cdks are also negatively regulated by phosphorylation of specific inhibitory sites [ 27].

Substrate recognition is tightly regulated by phosphorylation of specific motifs in the target proteins called Cdc4 phosphodegrons (CPDs) [ 3].

Ligand binding to ErbB receptors results in dimerization and activation of their intrinsic kinase activity followed by phosphorylation of specific tyrosine residues in the receptor cytoplasmic tails.

The regulation of gap junctions is controlled by phosphorylation of specific sites (mostly serine sites) on the carboxy-terminal tail region of the connexins [ 31].

In the classical NF-κB activation pathway IKKα and IKKβ are activated by phosphorylation of specific serine residues in the activation loop, and is thereby able to induce serine phosphorylation of IκBα [ 27].

Differences between H3 variants recognized frequently involve the presence or absence of discrete putative phosphorylation sites (e.g. S/N10, S/T/A28, S/T/A31, S/A96), suggesting a cell cycle dependent regulation by phosphorylation of specific H3 variants.

In addition, binding of HES6 to HES1 seems to cause proteolytic degradation of the heterodimer, mediated by phosphorylation of a specific serine residue in HES6 [13], [13].

We propose that protein complexes assembled by the R2TP complex are defined by phosphorylation of a specific motif and recognition by the PIH1D1 subunit.

However, while homotrimerization is sufficient for DNA binding and nuclear translocation, the magnitude and duration of transcriptional activity are regulated by inducible phosphorylation of specific serine residues of HSF1 by several protein kinases (Erk1/2, glycogen synthase kinase, protein kinase C) [ 64].

STAT3 is both a cytoplasmic signaling molecule and a nuclear transcription factor that is activated by the phosphorylation of specific tyrosine residue in its carboxyl-terminus by JAK kinases in response to cytokines, including IL-6, IFN, epidermal growth factor, and FGF [ 26, 27].

Enzymatic activity of eNOS is regulated by multiple phosphorylation of specific sites on the eNOS protein [ 10].