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Thus, CGTases most likely evolved from a common ancestor to diversify in product specificity by acquisition of specific mutations at the substrate binding sites.
Resistance to tetracycline (tet(M)), chloramphenicol (cat) and macrolides (erm(B) and/or mef(A/E)) is generally conferred by acquisition of specific genes that are associated with mobile genetic elements, including those of the Tn 916 and Tn 5252 families.
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The implementation of informative BRCA1 testing programs is aided by acquisition of population-specific genetic data.
Despite their broad host diversity, adaptation of individual strains to particular hosts occurring by acquisition of host-specific gene pools and/or loss of dispensable genetic material has been suggested in recent studies (Herron-Olson et al. 2007; Lowder et al. 2009).
Phagosomes fuse with early endosomes and then with late endosomes, as demonstrated by the acquisition of specific markers such as early endosome antigen-1, the small GTPases Rab5 and Rab7, and lysosome-associated membrane protein (Lamp -1, respectiveLamp -1
It is now clear that several different subtypes of CRC exist, defined by the acquisition of specific different genetic abnormalities that drive the cell transformation.
Differentiation presumes acquisition of specific properties by cells and increase of their heterogeneity.
Embedded in this is the acquisition of specific skills by each individual including, life charting, recognition of early warning signs, problem solving and other forms of coping, sleep hygiene and care planning, as well as general skills of actively participating and working collaboratively in the groups.
Differentiation was accompanied by changes in cell morphology, polyploidization and acquisition of specific MK markers (CD41).
The phylogenomic approach here employed allowed to trace along the evolutionary tree the acquisition of specific biochemical functions by the SMO and APAO subfamilies.
The lineage-specific amplifications observed, among which the one detected in mammals is the most extensive, are probably linked to the acquisition of specific, potentially novel functions by the newly-emerged duplicates.
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