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Investigators have suggested that αB-crystallin does not alter the polymerization state of IF proteins in primary astrocytes, but ectopic expression of αB-crystallin in the absence of stress can modify the organizational state of IF and αB-crystallin can function as an IF debundling protein [53].
The expression of GPC3 is silenced in human breast cancer, but ectopic expression of GPC3 revealed that this molecule can act as a negative regulator of breast cancer cell growth [ 37, 39].
Down regulation of GRCD2 in transgenic plants affects on all these processes, but ectopic expression of GRCD2 does not lead to observable phenotypes, indicating that this protein's activity is dependent on additional factors.
The role of FGF-6 in adult myogenesis is much less known, but ectopic expression of both FGF-2 and FGF-6 in transplanted myoblasts increased their contribution to de-novo muscle formation [ 29, 30].
The sensitivity of the mandibular tissue to Juvenile Hormone (JH) was previously shown in males, but ectopic expression of JH in female mandibular tissue did not lead to an increase in mandible size, suggesting a sex-specific tissue response to JH during development [ 86].
Similar(55)
Not only have altered expression levels of HB genes been detected in a variety of human malignancies [ 8, 11- 14], but the ectopic expression of certain HOX genes can induce tumors [ 15- 17].
It is specifically expressed in PA-accumulating cells in Arabidopsis but can induce ectopic expression of the BAN gene when constitutively expressed in the presence of a functional TT8 protein [ 10].
The repression of the pCRE of rx2 by Her9 and Gli3 in the CMZ in this experiment not only affects the endogenous Rx2 but also the ectopic expression of the repressors.
In Traf6 −/− cells, Q145N but not 2ED MAVS was completely defective in inducing IFNβ, but this defect was rescued by ectopic expression of WT but not C70A TRAF6.
In some, but not all, experiments, ectopic expression of RNR1 in wild-type or rad9Δ cells enhanced arrest with a G1 content of DNA induced by nutrient depletion (Fig. 4A, "wild type" and "rad9Δ"; Fig. 4B and E).
Consistently, the Mdm4 protein half-life was significantly shortened upon Rps27l disruption in MEFs or upon RPS27L knockdown in H1299 cells, but significantly extended upon ectopic expression of RPS27L in H1299 cells.
Related(13)
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