breach of tolerance

USAGE SUMMARY

The phrase "breach of tolerance" is correct and usable in written English.
It can be used in contexts discussing violations of accepted limits or standards of tolerance, often in social, political, or ethical discussions. Example: "The recent events have led to a significant breach of tolerance within the community, sparking widespread debate."

✓ Grammatically correct

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

19 human-written examples

A major concept in autoimmunity is that disruption of Foxp3+ regulatory T cells (Tregs) predisposes to breach of tolerance.

Journal of Autoimmunity

However, there is increasing recognition that understanding the immunobiology of target tissues will also have direct relevance to disease natural history, including breach of tolerance.

Journal of Autoimmunity

Therefore, it is probable that other immune abnormalities contribute to the breach of tolerance in NZB dTg mice.

Plosone

While our findings suggest a role for BAFF in the breach of tolerance in NZB dTg mice they do not precisely recapitulate those in BAFF-Tg dTg mice.

Plosone

Treatment with anti-CD4 mAb significantly reduced anti-HEL Ab production in NZB dTg mice (Figure 3D), suggesting that CD4+ T cell help contributes to the breach of tolerance in these mice.

Plosone

In addition, production of autoAb in NZB dTg mice is T cell-dependent, while T cells are not required for the breach of tolerance in BAFF-Tg dTg mice.

Plosone

Human-verified similar examples from authoritative sources

Similar Expressions

41 human-written examples

Detection of autoimmune T cells has not yet reached routine diagnostics, but with the development of tetramer and ELISPOT technologies it seems likely that autoantibody detection will serve as the method of choice for the identification of autoimmunity and breaches of tolerance (Fig. 1).

Arthritis Research and Therapy

The characterization of the I-Ab restricted AQP4 T cell epitopes, will now allow us to investigate the mechanisms that result in the breach of immunological tolerance against AQP4 and also why immunopathology develops in the CNS while other AQP4 expressing tissues are relatively spared.

Plosone

Recent evidence suggests a role for Th17 cells in the breach of immune tolerance.

Arthritis Research and Therapy

These results suggests that Th17 cells might play a role in the breach of immune tolerance.

Arthritis Research and Therapy

Based on indirect evidence, it has originally been suggested that ELN may play a role in the breach of peripheral tolerance and thereby may fast-track autoimmunity [ 25].

Arthritis Research and Therapy

Expert writing Tips

Best practice

When discussing medical or immunological conditions, use "breach of tolerance" to describe the failure of the immune system to recognize and accept self-antigens. It accurately conveys the severity and implications of this immune system dysfunction.

Common error

Avoid using "breach of tolerance" to describe mere disagreements or differences of opinion. This phrase specifically refers to a breakdown in immunological or social acceptance, not just a lack of consensus.

Linguistic Context

The phrase "breach of tolerance" functions primarily as a noun phrase, often serving as the subject or object of a sentence. It describes a specific event or condition where established limits of tolerance are violated. As Ludwig AI explains, this phrase is indeed correct and usable in written English.

Expression frequency: Common

Frequent in

Science

65%

News & Media

30%

Formal & Business

5%

Less common in

Encyclopedias

0%

Wiki

0%

Reference

0%

Ludwig's WRAP-UP

In summary, the phrase "breach of tolerance" is a grammatically sound and commonly used expression, particularly in scientific and medical domains, as confirmed by Ludwig. It describes the violation or breakdown of established tolerance limits, whether in the immune system or social contexts. While the register is typically formal and scientific, it also appears in news and media. Related phrases include "loss of tolerance" and "breakdown of tolerance". When using this phrase, ensure it accurately reflects a failure in immunological or social acceptance rather than mere disagreement.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

Loss of tolerance

Focuses on the disappearance of tolerance rather than the act of violating it.

Failure of tolerance

Emphasizes the ineffectiveness or breakdown of the tolerance mechanism.

Breakdown of tolerance

Highlights the process of tolerance collapsing or ceasing to function.

Violation of tolerance

Directly indicates an act against the state of tolerance.

Overcoming tolerance

Suggests an active process of surpassing the established tolerance.

Disruption of tolerance

Emphasizes the disturbance or interruption of a tolerant state.

Erosion of tolerance

Indicates a gradual decline or weakening of tolerance.

Transgression of tolerance

Implies crossing a defined boundary of acceptable tolerance.

Compromising tolerance

Suggests a situation where tolerance is weakened or put at risk.

Circumventing tolerance

Implies finding a way to bypass or avoid the limitations of tolerance.

FAQs

How can I use "breach of tolerance" in a sentence?

You can use "breach of tolerance" to describe situations where an established limit or norm of tolerance is violated, particularly in medical or social contexts. For example: "The autoimmune disease resulted from a "breach of tolerance" to self-antigens."

What is the difference between "loss of tolerance" and "breach of tolerance"?

"Loss of tolerance" refers to the state of no longer having tolerance, while "breach of tolerance" implies an active violation or breakdown of an existing tolerant state. You could use "loss of tolerance" to refer to the general condition.

What are some alternative phrases for "breach of tolerance"?

Some alternative phrases include "failure of tolerance", "breakdown of tolerance", or "violation of tolerance", depending on the specific nuance you wish to convey.

In what contexts is "breach of tolerance" most commonly used?

"Breach of tolerance" is frequently used in scientific and medical literature to describe immunological responses, as well as in discussions of social and political norms where acceptance or tolerance is violated.