Sentence examples for breakdown of tolerance from inspiring English sources

Tonight General Musharraf, who took power in a bloodless coup in 1999 and soon began questioning the breakdown of tolerance and law, issued his most sweeping statement yet on extremism, intolerance and violence in Pakistan, whose founders had a vision of a more moderate Islamic nation.

Breakdown of tolerance leads to autoimmunity due to emergence of autoreactive T or B cell clones.

Regardless of their function, auto-reactive antibodies are believed to arise as a result of a breakdown of tolerance towards self antigens [18].

The failure to control these responses leads to a breakdown of tolerance towards resident microbiota and has been proposed as one mechanism involved in the development of inflammatory bowel diseases (IBD) [3].

Breakdown of tolerance at the gut level may contribute to the development of IBD [ 19].

Ultimately, breakdown of tolerance and true autoimmunity against the native proteins ensue, possibly by epitope spread.

Breakdown of glucose tolerance status of the cohort at baseline was 74.1, 18.7, 7.2, and 2.7% for normal glucose tolerance, IGT, IFG, and combined IGT and IFG, respectively.

Moreover, study of gene-manipulated animals that develop systemic autoimmune diseases has provided insights into the mechanisms of maintenance and breakdown of self tolerance.

Failure or breakdown of immunological tolerance is believed to result in autoimmune disorders and CD4+CD25+ regulatory T cells (Tregs) have shown to be pivotal players in the maintenance of immune tolerance [4].

Our results, showing that IL-2 immune complex can promote the breakdown of peripheral tolerance by memory-like CD8+ T cells in the absence of CD4+ T cells help, have important implications for the development of therapies for autoimmune diseases as well as cancer immunotherapies.

The breakdown of peripheral tolerance in autoimmune patients might be a result of defective DC.