Sentence examples for failure of tolerance from inspiring English sources
One possibility is that in each disease there is a failure of tolerance, the careful training performed by the thymus gland to ensure that new white blood cells learn to be tolerant of the body's own tissues.
Moreover, considering that activation rather than presence of autoreactive T cells is the hallmark of autoimmune disease, the creation of an environment resulting in failure of tolerance and regulatory mechanisms, rather than emergence of novel microbial antigenic determinants, may well be at the root of autoimmunity.
Autoimmune diseases, such as MS, may result from the failure of tolerance mechanisms to prevent expansion of inflammatory autoreactive T cells.
An alternative is that a lack of exposure to infectious agents early in life results in a failure of tolerance in the immune system: the "hygiene hypothesis"[12].
Murine models for studies on self-reactive B cells localised the failure of tolerance mechanisms in the bone marrow [ 40].
Thus inadequate local IFN-γ production in C1qa−/− and C3−/− mice may well contribute to rapid rejection of the male grafts and to the failure of tolerance induction with HY peptide.
Allergic asthma is characterized by a failure of immune tolerance and the development of pathologic responses to inhaled aeroallergens, and vitamin D has been extensively shown to support immune regulation.
Accordingly, failure of maternal tolerance to the fetus has been suggested as a mechanism of adverse pregnancy outcomes: recurrent pregnancy loss, fetal growth restriction, and preeclampsia [9] [11].
Persisting nontreponemal antibodies after effective therapy may thus represent failure of immune tolerance rather than lack of pathogen clearance.
Certainly, polyendocrinopathy syndromes, and possibly sporadic variants of these diseases, appear to be characterized by failure of central tolerance [ 60].
This model highlights the role of innate and adaptive immune system interactions in the failure of peripheral tolerance.
