Sentence examples for both potency and selectivity from inspiring English sources

Finally, two substructure analysis pipelines singled out chemical substructures implicated in both potency and selectivity in agreement with the literature.

The cell-free and cell-based assay data showed that both potency and selectivity changed with the change in zinc-binding group.

This work describes the discovery of ITK inhibitors through structure-based design where high-resolution crystal structural information was used to optimize interactions within the kinase specificity pocket of the enzyme to improve both potency and selectivity.

In the last period, with the help of X-ray crystallography, much progress has been achieved for the drug-design of selective CA IX inhibitors, by considering the three main structural elements that govern both potency and selectivity, that is, a zinc binding group (ZBG), an organic scaffold, and one or more side chains substituting the scaffold.

Because they covalently modify the catalytic residue of the targeted enzyme, they can be used in competition assays to assess both potency and selectivity of compounds in intact cells, extracts and even whole organisms [7], [8].

The activity and specificity of AMD3100 was such that it surpassed all known anti-HIV agents in both potency and selectivity.

These findings have provided a new chemical template for non-covalent proteasome inhibitors, which is ready for further structural optimization to improve both potency and subunit selectivity.

Inhibitors of a human aldo keto reductase, AKR1B10, are regarded as promising therapeutics for the treatment of cancer, but those with both high potency and selectivity compared to the structurally similar aldose reductase (AKR1B1) have not been reported.

However, because of the high sequence homology of different isozymes in the substrate binding pocket, developing inhibitors with both potency and excellent isoform selectivity remains a challenging problem.

In this study, both compounds showed improved potency and selectivity for CD22 (IC50 70 nM) and 712-fold more selective for CD22 than for MAG.

In summary, a number of criteria were applied to select hits from the initial screen: potency and selectivity against both enzyme and parasite; druglikeness, particularly the probability of blood brain barrier permeability; and chemical tractability.