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This led to the establishment of the concept of dynamic systemic resolution (DSR), in which selective, kinetically controlled routes are coupled to the dynamic systems.[ 21] Especially enzyme-catalyzed reaction pathways present an efficient methodology,[ 22– 28] applying both catalysis and selectivity on the systems.
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As you suggest: more complex amino acids were, to some extent, selectively advantageous (because of both catalysis and fermentation).
With this probe, new data was acquired further defining the α-exosite's role in both catalysis and protein stability.
The bio-significance and potential application of chiral-at-metal complexes are discussed, such as the synergistic effect of catalysis and chiral selectivity of the metal center in enzymes.
Structural studies on MBLs have revealed the importance of mobile regions in catalysis and substrate selectivity.
We appreciate that other factors, for example, ancillary non-catalytic domains, targeting proteins, protein conformation, co-substrate and inhibitor availability, substrate length (peptide/protein), and cellular compartmentalization, may alter hydroxylation and demethylation catalysis and substrate selectivities in a cellular context.
The obtained results highlight the importance of correlating water concentration with both enzyme activity and selectivity.
Considering both cytotoxic parameters and selectivity index, TTHL displayed the best profile in MCF-7 cells.
These include a mobile α3 region which is important in catalysis and determining inhibitor selectivity.
Dimerization of ethene can be considered as coordination catalysis at active sites of Ni(I), while oligomerization of propene proceeds via dual catalysis due to both coordination catalysis and acid catalysis.
These results suggest that α-exosite binding can both enhance catalysis and stabilize BoNT/A protease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com