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In the meantime, other HIV inhibitors that outweighed d4T were discovered in both potency and safety, the most prominent being TDF (tenofovir disoproxil fumarate).
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As a consequence, active ranges identified by MAA models have both the desired requirements of a drug molecule, i.e., high potency and safety.
This can pave ways to prospectively determine the potency and safety of vaccines and adjuvants.
Bi-functional design may further enhance potency and safety of RNAi-based therapeutics.
The introduction of lipid nanoparticle bupivacaine has paved a way for several randomized trials investigating the potency and safety of this new delivery system (Table 3).
Objective: To investigate the in vivo contraceptive potency and safety of a novel microemulsion-based lipophilic vaginal spermicide.
Good predictability, high potency, and safety of the active ranges in the proposed MAA-based models will naturally provide ease in furnishing lead structures for the development of potent but safe anti-HIV purine nucleoside analogs.
To compare the anesthetic potency and safety of spinal anesthesia with higher dosages of levobupivacaine and bupivacaine in patients for bilateral sequential for total knee arthroplasty (TKA).
This chapter reviews existing regulatory approved methods designed to provide information on potency and safety of complex biological medicines with an insight into strategies considered for alternative procedures.
Along with improved potency and safety, the system saves time by providing easy, ready-touse RNA reagents that also reduce cell toxicity by avoiding activation of cellular innate immune responses.
Nevertheless, establishment of general strategies and guidelines on how to assess potency and safety of hPSC-derived cellular products is critical, and close interactions with the regulatory agencies are very important in order to safely translate experimental cell therapy to the clinic.
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