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The levels of significance between continuous variables of the biological markers were calculated with Spearman's rank correlation test (rs).

Spearman correlation coefficient (r) was used to assess the correlation between continuous variables of indexes (DAS-28, CDAI and SDAI).

Correlations between continuous variables of the three uPA system components were assessed by Spearman's rank correlation coefficients (rs).

The levels of significance between continuous variables of biological markers were calculated using Spearman's rank correlation (rs).

Correlations between continuous variables of the biological markers were calculated by Spearman's rank correlation test (r s ).

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Student's t-test was used to determine the significance of differences between continuous variables for the two groups, except for calculations on subgroups with no medication where Mann Whitney U-test was used.

2 Sample size: EE 101, DP 101, PA 99 The correlations between continuous variables and dimensions of burnout are presented in Table 4. DP was positively associated with age, number of children, and number of years in the profession.

Given the presence of three groups, differences between continuous variables, including the number of SNPs tested, were calculated using one-way ANOVA; a post-hoc analysis with Bonferroni correction was made for multiple comparisons.

Data were transformed into natural logarithms to allow the investigation of power relations between continuous variables and proportional (percentage) effects of discrete variables.

Student's paired t-test was used to test for significant differences between continuous variables including the amount of energy (kJ/day) and iron (mg/day) offered from complementary foods from the three-day diet records.

Comparison between two continuous variables of normal distribution was carried out using the t-test.

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