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Further, it has been reported that these substances decrease Cox-2 mRNA levels, which could be mediated through modulation of promoter activity [13], [30].

In summary, the data of the present study show no regulatory role of human caspase-12 on the inflammation induced by TLR ligands or Yersinia spp. Although a role of caspase-12 for the susceptibility to sepsis can still be envisaged (which has to be confirmed in larger studies), this is highly unlikely to be mediated through modulation of cytokine response.

This effect appears to be mediated through modulation of thermogenesis.

Some of the atherogenic risk associated with LDL, in particular oxidized LDL, could be mediated through modulation of the availability of active TGF-β1 in the vasculature.

One of the pleiotropic properties of these foods could explain their disease-protective potentials, which could be mediated through modulation of PI3K/AKT/PTEN pathway.

One of the pleiotropic properties of these foods could explain their disease protective potentials, which could be mediated through modulation of the PI3K/ AKT/GSK-3β pathway.

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Another potential interpretation of the present data is that the inhibition of the N20 response in the left S1 by conditioning the homologous S1 is mediated through modulation of both M1.

As zerumbone inhibited post-IR DNA repair and enhanced radiation-induced G2/M arrest, we checked if those effects were mediated through modulation of intracellular oxidative stress.

We previously demonstrated that intra-articular glucocorticoids decrease the synovial tissue (ST) T-cell population and therefore aimed to investigate whether this is mediated through modulation of apoptosis.

Taken together, our data suggest that the partial protective effect imposed by metformin is mediated through modulation of p38 MAPK activation, downstream of AMPK signaling.

Since p57Kip2 has been found to physically interact with and inhibit JNK/SAPK, we investigated whether the cardioprotective effects of p57Kip2 were mediated through modulation of the JNK stress signaling pathway.

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