Sentence examples for be mediated through suppression from inspiring English sources

Importantly, this inhibition could be mediated through suppression of integrin-mediated mechanisms [ 24].

This function of NCTS might be mediated through suppression of NF- κB and iNOS signaling pathways.

They speculate this could be mediated through suppression of signaling through mTOR and S6K1, and that this might contribute to improved mitochondrial function and reduced ROS.

In vitro anti-inflammatory actions of IL-6 are mediated through suppression of interferon gamma (IFNγ) [1].

We therefore hypothesized that one of the possible mechanisms for the fibrogenic effects of adenosine is mediated through suppression of Fli1 expression.

Many studies have reported that TNF-α-induced NF-κB activation is involved in upregulating MMP-9 transcriptional activity; thus, we determined whether the inhibitory effect of SSeo on TNF-α-induced activation of MMP-9 is mediated through suppression of NF-κB signaling by measuring the nuclear translocation of NF-κB.

Given that the suppression of survivin expression by YM155 is mediated through inhibition of the transcriptional activity of the survivin gene promoter (Nakahara et al, 2007), it is possible that YM155 also inhibits the expression of these survivin variants.

In conclusion, T. luteostoma extract has antipyretic and anti-inflammatory activities, which may be mediated through the suppression of production of PGE2, cAMP, Na+/Ca2+, TNFα, IL-1β, IL-2, and IL-6.

However, data suggest that any beneficial effect of MSCs may be mediated through the suppression of the Th1 and Th17 driven responses along with an increased antigen specific T regulatory cell response [ 40, 48, 49].

Although the mode of action of tofacitinib has remain unclear, we clarified thatthe inhibitory effects of tofacitinib could be mediated through the suppression of IL-17 and IFN-γ production and proliferation of CD4+ T cells, presumably Th1 and Th17 cells by in vitro experiments.

As aberrant BCR promotes the expression of the pro-glycolytic protein C-MYC (Mahon et al, 2003), decreased glycolysis in response to imatinib treatment could be mediated through C-MYC suppression.