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Exact(9)
Researchers can also make conditional knockouts, mice in which a gene of interest can be inactivated in a specific tissue or part of the brain, at any stage in life.
However, it is possible that a higher proportion of normal X chromosomes will be inactivated in a given individual, with the resultant appearance of symptoms of disease in various degrees.
Since the proportion of Mecp2-deleted X chromosomes that will be inactivated in a given female animal is unpredictable, we decided to use Mecp2-/y male mice that correspond to a complete absence of the Mecp2 gene product in all cells (i.e., a real null phenotype) [20].
Related protein, RASSF1A (Ras association domain-containing protein 1), can be inactivated in a similar fashion.
Conditional mice in which Foxp2 can be inactivated in a spatially and temporally selective manner [37] should allow separation of developmental and online functions.
Together with our results of DLEC1 methylation in CRC and gastric cancers, DLEC1 is likely to be inactivated in a wide range of tumours by promoter methylation and plays an important role in multiple tumorigenesis.
Similar(51)
In X-linked diseases, females may show a severe phenotype as a consequence of skewed X-chromosome inactivation, resulting in a higher percentage of the wild-type X-chromosome being inactivated in a specific tissue.
Both viruses were inactivated in a time-dependent manner.
Now comes a possible explanation: An antibiotic that the lung normally produces is inactivated in a salty environment.
During exposure to UVB-light, ALDH3A1 was inactivated in a time dependent manner.
In cells of the embryo proper, either the paternal or the maternal X chromosome is inactivated in a random fashion.
Related(20)
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