Sentence examples for associated mutants from inspiring English sources

It indicates that expressions of all fCJD associated mutants induce cytotoxicity.

Site directed mutagenesis was employed to create the disease associated mutants A30P, E46K and A53T of αS as previously described [16] using primers produced by MWG, Germany.

Of these three additional THO associated mutants, only thp1Δ was detected in the initial diploid DOX screen (Table 1, Supplemental Table S1).

Figure 4(i) shows a plot of the A562 against time for the assay on the lysates from cells normally expressing αS and overexpressing the protein and its disease associated mutants.

It has been reported that the levels of mature, endoproteolytically cleaved, LRP in the murine nervous system are reduced when AD associated mutants of PS1 (M146L or L286V, expressed via the hamster prion protein gene promoter) are present [27].

The accumulation of activated Erk1/2 in the cytoplasm suggests that the CMT2B associated mutants retard kinase shuttling to the nucleus, which is required to upregulate the genes responsible for differentiation of sensory neurons.

In contrast, CD-associated mutants failed to recruit ATG16L1 to the plasma membrane and wrapping of invading bacteria by autophagosomes was impaired [31].

Interestingly, three human NPHP9-associated mutants retain full kinase activity.

Misprocessing of CF-associated mutants S945L, H949Y, and D979A has previously been demonstrated, perhaps indicating that these residues are particularly critical for normal protein processing.

Davidson et al. [ 15] also found that different ARB-associated mutants lead to the same disease phenotype but through different effects on cellular processing mechanisms.

In marked contrast to the TB5 domain MFS mutants, all of the acromelic dysplasia-associated mutants we investigated were able to associate with fibroblast-derived microfibrils in the GFP-Fbn co-culture assay.