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In this perspective, we summarize current PTEN-targeting strategies and discuss potential approaches to modulate its functional dose, considering all stages of PTEN biogenesis from direct protein modulation to the targeting of relevant miRNAs as well as the PTEN gene and mRNA.
New approaches to modulate recipient immune response are needed.
Therefore, the introduction of thermosensitive polymers on polymeric nanoparticles might be a potential approaches to modulate drug release behaviors.
These post-translational modifications of cGAS provide essential approaches to modulate cGAS activities during innate immune responses.
In this review, we summarize the recent development of metabolic engineering approaches to modulate yeast metabolism with representative examples.
Encouraging in vitro data originally showed that approaches to modulate PKC activity through small-molecule inhibitors or genetic manipulation could affect tumor cell survival.
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To date, micro-scale approaches to modulating cell-ECM interactions and cell-cell contacts have provided insight into how in vitro niches can regulate stem cell fate.
2 As a means to enhance the prospects for molecular materials, approaches to modulating reversibly molecular NLO properties have attracted considerable attention recently.
In cancer contexts such as colorectal cancer where upregulated WNT/β-catenin is mediated by constitutively activating downstream mutations in CTNNB1 or APC, therapeutic approaches to modulating WNT/β-catenin signalling have been somewhat limited.
RNA interference represents a novel therapeutic approach to modulate several neurodegenerative disease-related genes.
Thus, antioxidant principles from natural sources can provide a multifaceted approach to modulate oxidative imbalance found in human degenerative diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com